Objective: This study was conducted for the purpose of examining loneliness, depression and burnout in the employees of factory. Materials and Methods: This descriptive and correlational research was conducted at a workplace in Istanbul. The universe of the study comprised the employees of the workplace (N=300) and the sample’ consisted of 265 employees. The data were collected using the Personal Information Form, the UCLA Loneliness Scale (Version 3), the and the Beck Depression Inventory and Maslach Burnout Inventory. Results: The mean age of the participants was 33,99±8,15 years. Of the participants, 78,9% were men, 51,7% were elementary school graduates and 83,0% were laborers. The UCLA loneliness scale mean score of the participants was 39,83±8,98; their BECK depression inventory mean score was 8,06±7.66 and out of the subdimensions of the Maslach Burnout Inventory, mean scores for emotional exhaustion were 20,05±7,17, 8,78±3,94 on the desensitization and 27,90±6,26 on the personal accomplishment subscales. Statistically significant relationships were found between employees' UCLA loneliness, BECK depression and Maslach Burnout Inventory scale scores (p˂0,05). Conclusion: The findings of this research show that there are relationships between employees' loneliness, depression and burnout scores.