The purpose of this study was to analyze the level of 21st century learning skills according to various variables. The sample of this study, in which the descriptive survey model is used, consisted of 920 students who study in 6th, 7th and 8th grades of secondary schools in the central districts of Van province which are Ipekyolu, Tuşba and Edremit in the 2017-2018 academic year. In order to determine the level of 21st century learning skills of secondary school students, "21st Century Learning Skills Scale" was used. Descriptive statistics and differential statistics were used in the analysis of research data. As a result of study, it was determined that secondary school students' 21st century learning skills are at high level in general. The students' active learning skills were found to be at moderate level whereas it was concluded that learning to learn, problem solving, cooperation and communication skills are at high level. It was concluded that female students compared to the male students, 7th grade students compared to 6th and 8th grade students, the students having the opportunities for utilizing technological tools such as computers, smart phones and tablet computers compared to the ones who do not have, have a higher level of 21st century learning skills. In this case, it is advisable to create studentcentered teaching-learning environments in which secondary school students will be active in the process and will be responsible for learning in order to develop their active learning skills and 21st century learning skills in general.